Rocuronium Uses, Side Effects & Warnings
Rocuronium is used to relax the muscles. It works by blocking the signals between your nerves and your muscles. Rocuronium is given before general anesthesia in preparing you for surgery. Rocuronium helps to keep your body still during surgery. It also relaxes your throat so a breathing …
Rocuronium bromide (NDC 0409-9558-05 and 0409-9558-10) (rocuronium …
For sevoflurane (induction) rocuronium bromide doses of 0.45 mg/kg and 0.6 mg/kg in general produce excellent to good intubating conditions within 75 seconds. When halothane is used, a 0.6 mg/kg dose of rocuronium bromide injection resulted in excellent to good intubating conditions within 60 seconds. The time to maximum block for an intubating ...
Rocuronium
of rocuronium bromide infusion may be expected to proceed at rates comparable to that . see Clinical Pharmacology (12.2)]. Infusion solutions of rocuronium bromide can be prepared by mixing rocuronium bromide with an appropriate infusion solution such as 5% glucose in water or lactated Ringers [see Dosage and Administration (2.6)
Zemuron (Rocuronium Bromide Injection): Uses, Dosage, Side
The chemical formula is C 32 H 53 BrN 2 O 4 with a molecular weight of 609.70. The partition coefficient of rocuronium bromide in n-octanol/water is 0.5 at 20°C. ZEMURON is supplied as a sterile, nonpyrogenic, isotonic solution that is clear, colorless to yellow/orange, for intravenous injection only. Each mL contains 10 mg rocuronium …
Intramuscular Rocuronium | Anesthesiology | American …
Intramuscular Rocuronium. Anesthesiology February 1997, Vol. 86, 506. To the Editor:-The recent article by Reynolds et al. [1] describing intubating conditions after intramuscular rocuronium raises two issues. First, the aim of this study was to develop a technique to facilitate tracheal intubation for children in whom intravenous access is not ...
Rocuronium
Rocuronium is a non-depolarizing neuromuscular blocker widely used to produce muscle relaxation to help facilitate surgery and …
Rocuronium Monograph for Professionals
Rocuronium (Monograph) Drug class: Neuromuscular Blocking Agents. VA class: MS200. Chemical name: 1- [ (2β,3α,5α,16β,17β)-17- (acetyloxy)-3-hydroxy-2- (4 …
Rocuronium bromide: Uses, Dosage, Side Effects, FAQ
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. Rocuronium bromide, like vecuronium is longer acting in infants than in children. However, unlike vecuronium, rocuronium retains the characteristics of an intermediate-acting …
Drug Shortage Detail: Rocuronium Bromide Injection
Mylan Institutional states the reason for the shortage was increased demand. [2] Hospira has a consistent supply of rocuronium injection. [3] Teva is not currently manufacturing rocuronium injection. [4] Fresenius Kabi has rocuronium injection available. [5] Sagent cites increased demand as the reason for this shortage.
Zemuron (rocuronium) dosing, indications, interactions, …
fentanyl transmucosal, rocuronium. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death.
NEW ZEALAND DATA SHEET
A dose of 1.0mg rocuronium bromide per kg body weight is recommended for facilitating tracheal intubation conditions duringrapid sequence induction of anaesthesia, after which adequate intubation conditions are also established within 60 seconds in nearly all patients. If a dose of 0.6mg rocuronium bromide per kg body weight is
Rocuronium (Intravenous Route) Side Effects
tightness in the chest. Difficulty with swallowing. hives, itching, or skin rash. muscular pain, tenderness, wasting, or weakness. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. unusual tiredness or weakness. Other side effects not listed may also occur in some patients.
Rocuronium bromide (NDC 0409-9558-05 and 0409-9558-10) (rocuronium
Rocuronium bromide should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE. Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use rocuronium bromide within 60 days. Use opened vials of rocuronium bromide within 30 days.
Rocuronium
Rocuronium. Keith Hillier, in xPharm: The Comprehensive Pharmacology Reference, 2007. Introduction. Rocuronium is one of a series of non-depolarizing skeletal muscle relaxant agents (also known as competitive muscle relaxants). Rocuronium has an amino-steroid structure and is structurally related to vecuronium; its action is rapid in onset and it is …
Rocuronium: Drug Basics and Frequently Asked Questions
Rocuronium is a medication injected into the vein that relaxes the muscles during surgery or certain procedures, including intubation (insertion of a breathing tube) or mechanical ventilation (preparation for a breathing machine). It's given as an add-on therapy to general anesthesia (medications that help you sleep and prevent you from feeling pain …
Zemuron (rocuronium) dosing, indications, …
Zemuron (rocuronium) dosing, indications, interactions, adverse effects, and more Administration Dose should be calculated based on ideal body weight Next: Interactions Enter a drug name and...
Rocuronium (Zemuron) | Davis's Drug Guide
Store rocuronium in refrigerator. IV Administration IV Administration. IV Administration. IV Push: Administer undiluted. Rate: Titrate according to patient response. Continuous Infusion: Dilution: 0.9% NaCl, sterile water for injection, D5W, LR injection, and D5/0.9% NaCl for infusion. Solution is stable for 24 hr at room temperature.
Rocuronium: View Uses, Side Effects and Medicines | 1mg
Rocuronium is given as an injection under the supervision of a doctor. It makes you feel dizzy or drowsy. Do not drive until you know how Rocuronium affects you. Your doctor will monitor your blood pressure regularly as the medicine may lead to high blood pressure. Inform your doctor if you are pregnant, planning pregnancy or …
Rocuronium bromide | Drugs | BNF | NICE
Neuromuscular blocking drugs, non-depolarising. View rocuronium bromide information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, …
Rocuronium bromide | Drugs | BNF | NICE
Neuromuscular blockade (intermediate duration) during intensive care for rocuronium bromide Initially by intravenous injection. Adult Initially 600 micrograms/kg, initial dose is optional; (by intravenous infusion) maintenance 300–600 micrograms/kg/hour for first hour, then (by intravenous infusion), adjusted according to response. ...
Intravenous infusion of rocuronium bromide prolongs …
For the rocuronium group (n = 18), rocuronium bromide was administered as an initial intravenous bolus of 5 mg/kg followed by continuous infusion at a rate of 250, 500, or 1000 μg/kg/min along with propofol infusion for 60 min. At the end of the infusion period, sugammadex (32 mg/kg) was injected, and the line was flushed with 0.5 mL …
Rocuronium: Generic, Uses, Side Effects, Dosages, Interactions
Serious side effects of Rocuronium include: hives, difficulty breathing, swelling of the face, lips, tongue, or throat, ongoing muscle weakness, and. loss of movement in any part of the body (especially in adults who are 65 and older) Rare side effects of Rocuronium include: none. This is not a complete list of side effects and other …
DailyMed
The partition coefficient of rocuronium bromide in n-octanol/water is 0.5 at 20°C. Rocuronium bromide is supplied as a sterile, nonpyrogenic, isotonic solution that is clear, colorless to yellow/orange, for intravenous injection only. Each mL contains 10 mg rocuronium bromide and 2 mg sodium acetate.
HIGHLIGHTS OF PRESCRIBING INFORMATION
Since rocuronium bromide is primarily excreted by the liver, it should be used with caution in patients with clinically significant hepatic impairment. Rocuronium bromide 0.6 mg/kg has been studied in a limited number of patients (n=9) with clinically significant hepatic impairment under steady-state isoflurane anesthesia.
Rocuronium bromide | DrugBank Online
Rocuronium bromide. Drug Entry. Rocuronium. Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during ...
Rocuronium
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent indicated as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal …
Rocuronium Bromide
mL, of Rocuronium Bromide in the Test solution; and r U and r S are Reference solution—Mix 33mL of Matching Fluid G and 67mL the peak responses for acetic acid obtained from the Test solution of water. and Standard solution, respectively: the content of acetic acid is not Test solution—Transfer 500mg of Rocuronium Bromide to a 50- more …
Rocuronium bromide (NDC 0409-9558-05 and 0409-9558 …
Rocuronium bromide (NDC 0409-9558-05 and 0409-9558-10) (rocuronium bromide) Clinical Pharmacology 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing …
Rocuronium Bromide
0.6 mg/kg rocuronium or 0.1 mg/kg of vecuronium.(23) Conversely, in children undergo-ing elective surgery with halothane anesthesia, rocuronium 0.45 mg/kg was inferior to 0.6 mg/kg for producing satisfactory intubating conditions.(17) In children 4–8 years old undergoing elective surgery, rocuronium 0.6 mg/kg with propofol 2.5 mg/kg provided
Rocuronium Bromide Formulation
Rocuronium Bromide 119302 -91-9 TLV-C 4 µg/m3 (OEB 4) Internal Wipe limit 40 µg/100 cm² Internal Engineering measures : All engineering controls should be implemented by facility design and operated in accordance with GMP principles to protect products, workers, and the environment. Essentially no open handling permitted.
Rocuronium: Dosage, Mechanism/Onset of Action, Half-Life
Tracheal intubation, surgical: Infants, Children, and Adolescents: Note: Inhaled anesthetic agents prolong the duration of action of rocuronium; use lower end of the dosing range; dosing interval guided by monitoring with a peripheral nerve stimulator. Initial: IV: 0.45 to 0.6 mg/kg.
The safety of high-dose rocuronium bromide in general …
Rocuronium bromide of 0.3 mg/kg/h was infused when Th recovered to 25%. Outcome measurement. Muscle relaxation-related indices . The patients were monitored for the onset time and duration of muscle relaxation as well as the duration of action, where the onset time of muscle relaxation refers to the time from the completion …
Rocuronium Monograph for Professionals
For continuous IV infusion, dilute rocuronium bromide injection to the desired concentration (e.g., 0.5, 1, or 5 mg/mL) in a compatible IV infusion solution (see Solution Compatibility under Stability). Use within 24 hours. Dosage. Available as rocuronium bromide; dosage expressed in terms of the salt.
DailyMed
Since rocuronium bromide is primarily excreted by the liver, it should be used with caution in patients with clinically significant hepatic impairment. Rocuronium bromide 0.6 mg/kg has been studied in a limited number of patients (n=9) with clinically significant hepatic impairment under steady-state isoflurane anesthesia.
Rocuronium | C32H53N2O4+ | CID 441290
It derives from a hydride of a 5alpha-androstane. Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation ...
Rocuronium bromide | 11
Rocuronium bromide (Zemuron) is a recently approved amino steroid neuromuscular blocking agent. It has a rapid onset of action (1 minute), but its duration of action is intermediate (55 minutes), about that of vecuronium. On rare occasions, it may release histamine and cause cardiac irregularities.
Drug Shortage Detail: Rocuronium Injection
Eugia has rocuronium injection available. Fresenius Kabi had rocuronium injection on shortage due to increased demand. Hikma has rocuronium injection on shortage due to increased demand. Pfizer has rocuronium on shortage due to manufacturing delays. Piramal Critical Care did not provide a reason for the shortage.
